TPTE

Across TCGA cell cohorts, TPTE RNA expression is significantly associated with the go_rna of many other GO terms, with 896 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TPTE-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase II promoter, Negative regulation of response to endoplasmic reticulum stress, and Positive regulation of telomere maintenance via telomere lengthening. Each is linked with TPTE in more than 5 cancer types. Because this analysis shows association rather than direction, both TPTE-to-partner and partner-to-TPTE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase II promoter grouped by TPTE-low versus TPTE-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPTE→partner) and Y-score (partner→TPTE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Transcription initiation at RNA polymerase II promoter →	+0.032	+0.581	.003	.006	3	6
SKIN	Negative regulation of response to endoplasmic reticulum stress →	+0.047	+0.833	.007	.008	3	5
BREAST	Positive regulation of telomere maintenance via telomere lengthening →	+0.067	+0.658	.004	.006	3	5
BLOOD_Myeloma	RNA (guanine-N7)-methylation →	+0.084	+1.281	.003	.002	3	5
SKIN	Response to histamine →	-0.188	-0.766	<.001	<.001	3	4
BLOOD_Leukemia	Trabecula morphogenesis →	-0.066	-0.519	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 896 associations by consensus.

Transcription initiation at RNA polymerase II promoter by TPTE expression — CNS

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