TPTE

Across TCGA cell cohorts, TPTE mutation is significantly associated with the RNA expression of many other genes, with 258 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TPTE-associated genes across cancer lineages are OR5AU1, RBMY1B, and RBMY1D. Each is linked with TPTE in more than 1 cancer types. Because this analysis shows association rather than direction, both TPTE-to-partner and partner-to-TPTE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by TPTE-low versus TPTE-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPTE→partner) and Y-score (partner→TPTE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	OR5AU1 →	+0.018	+3.459	<.001	.004	3	2
BONE	RBMY1B →	+0.030	+5.169	<.001	.004	3	2
BONE	RBMY1D →	+0.050	+5.169	<.001	.004	3	2
OESOPHAGUS	TNP2 →	+0.018	+3.392	.001	.007	3	2
SOFT_TISSUE	NEU2 →	+0.030	+3.297	.008	.008	3	2
URINARY_TRACT	IL22 →	+0.023	+5.087	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 258 associations by consensus.

OR5AU1 by TPTE expression — LIVER

Explore this box plot interactively →