TPT1-AS1

Across TCGA patient cohorts, TPT1-AS1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPT1-AS1-associated genes across cancer lineages are RN7SL140P, MIR4452, and MIR3692. Each is linked with TPT1-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPT1-AS1-to-partner and partner-to-TPT1-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL140P grouped by TPT1-AS1-low versus TPT1-AS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPT1-AS1→partner) and Y-score (partner→TPT1-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL140P →	+0.199	+4.997	<.001	.003	3	1
UCEC	MIR4452 →	+0.670	+5.292	<.001	.002	3	1
UCEC	MIR3692 →	+0.418	+5.292	.004	.002	3	1
UCEC	MIR4727 →	+0.766	+5.136	<.001	<.001	3	1
UCEC	MIR6857 →	+0.611	+4.943	<.001	<.001	3	1
UCEC	RNU6-1301P →	+0.671	+4.078	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RN7SL140P by TPT1-AS1 expression — UCEC

Explore this box plot interactively →