TPT1-AS1

Across TCGA pan-cancer cohorts, TPT1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TPT1-AS1 data layer.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher TPT1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TPT1-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and THYM show a favorable association.

PAAD, THYM, and READ are the cancer types where TPT1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Tertile	All	0.594	0.399	.003	45	view →
THYM	DFS	Tertile	II,III,IV	0.816	0.420	.001	42	view →
READ	OS	Tertile	III,IV	0.832	0.626	.003	32	view →
BLCA	DFS	Tertile	III,IV	0.385	0.693	.002	28	view →
OV	DFS	Median	III,IV	0.120	0.183	.014	20	view →
COAD	OS	Median	All	0.441	0.658	.003	19	view →
HNSC	OS	Median	II,III,IV	0.737	0.607	.005	19	view →
UVM	DFS	Median	II,III,IV	0.702	0.415	.020	18	view →
PRAD	DFS	Median	All	0.848	0.916	.016	16	view →
MESO	OS	Tertile	IV	0.757	0.363	.013	15	view →
LGG	OS	Median	All	0.855	0.764	.003	15	view →
KIRC	DFS	Tertile	II,III,IV	0.402	0.621	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TPT1-AS1–PAAD (DFS)

Open the PAAD breakdown →