TPT1-AS1

Across TCGA pan-cancer cohorts, TPT1-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TPT1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TPT1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TPT1-AS1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, UCEC, and BLCA are the cancer types where TPT1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPT1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.120	<.001	8	view →
UCEC	All	III,IV	−1.057	<.001	8	view →
BLCA	All	IV	−0.594	.001	8	view →
HNSC	Male	III,IV	+0.498	<.001	8	view →
LIHC	All	II,III,IV	+0.323	<.001	8	view →
KIRC	All	All	+0.203	<.001	7	view →
BRCA	All	III,IV	−1.531	<.001	6	view →
COAD	All	All	+0.422	<.001	5	view →
LUSC	All	III,IV	−0.601	.009	4	view →
CHOL	Male	All	+1.031	<.001	3	view →
KIRP	All	IV	+0.612	.012	2	view →
PAAD	All	All	+0.504	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TPT1-AS1–KICH

Open the KICH breakdown →