TPST2

Across TCGA patient cohorts, TPST2 mutation is significantly associated with the RNA expression of many other genes, with 263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPST2-associated genes across cancer lineages are SFPQP1, RNU6-165P, and RNA5SP72. Each is linked with TPST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPST2-to-partner and partner-to-TPST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFPQP1 grouped by TPST2-low versus TPST2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPST2→partner) and Y-score (partner→TPST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SFPQP1 →	+0.079	+3.661	<.001	.009	3	2
LUAD	RNU6-165P →	+0.528	+7.930	<.001	.008	3	2
UCEC	RNA5SP72 →	+0.253	+2.861	.003	.004	3	2
UCEC	SYPL1P1 →	+0.137	+2.631	<.001	.007	3	2
COAD	RNU6-502P →	+0.810	+6.392	<.001	.001	3	2
UCEC	NTAN1P1 →	+0.088	+3.767	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 263 associations by consensus.

SFPQP1 by TPST2 expression — SKCM

Explore this box plot interactively →