TPST2

Across TCGA pan-cancer cohorts, TPST2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TPST2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TPST2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TPST2 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

HNSC, THCA, and KIRP are the cancer types where TPST2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPST2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.924	<.001	12	view →
THCA	Male	III,IV	−1.755	<.001	11	view →
KIRP	Female	All	−1.519	<.001	11	view →
KIRC	Female	All	−0.634	<.001	10	view →
COAD	Female	All	+0.971	<.001	8	view →
LUAD	Female	II,III,IV	−0.663	<.001	8	view →
STAD	All	II,III,IV	+0.588	.003	4	view →
BRCA	All	All	−0.227	.003	4	view →
BLCA	All	III,IV	+0.620	.015	3	view →
READ	All	All	+0.637	.008	2	view →
PRAD	All	All	−0.489	<.001	2	view →
ESCA	All	All	+0.877	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TPST2–HNSC

Open the HNSC breakdown →