TPRX1

Across TCGA patient cohorts, TPRX1 mutation is significantly associated with the RNA expression of many other genes, with 1,333 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPRX1-associated genes across cancer lineages are SLC4A1APP2, HMGB1P7, and MTCO2P34. Each is linked with TPRX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPRX1-to-partner and partner-to-TPRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC4A1APP2 grouped by TPRX1-low versus TPRX1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRX1→partner) and Y-score (partner→TPRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC4A1APP2 →	+0.042	+5.339	<.001	.003	3	3
COAD	HMGB1P7 →	+0.881	+4.739	<.001	.001	3	3
READ	MTCO2P34 →	+0.296	+5.925	<.001	.002	3	2
READ	PRELID3BP2 →	+0.335	+6.681	<.001	<.001	3	2
UCEC	MIR7702 →	+0.202	+4.060	<.001	.006	3	2
UCEC	MIR8082 →	+0.363	+2.183	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,333 associations by consensus.

SLC4A1APP2 by TPRX1 expression — HNSC

Explore this box plot interactively →