TPRX1

Across TCGA pan-cancer cohorts, TPRX1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TPRX1 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TPRX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TPRX1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

THYM, KICH, and READ are the cancer types where TPRX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.311	0.895	<.001	51	view →
KICH	OS	Tertile	III,IV	0.178	0.761	.001	45	view →
READ	DFS	Tertile	III,IV	0.209	0.787	<.001	39	view →
COAD	OS	Tertile	IV	0.082	0.659	<.001	36	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	27	view →
ACC	OS	Quartile	II,III,IV	0.631	0.939	.006	24	view →
SCLC	DFS	Tertile	All	0.135	0.714	<.001	24	view →
CESC	OS	Tertile	IV	0.235	0.606	.044	18	view →
LGG	DFS	Tertile	All	0.264	0.428	.003	18	view →
LIHC	DFS	Tertile	All	0.328	0.555	.020	9	view →
HNSC	OS	Tertile	IV	0.545	0.370	.045	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

TPRX1–THYM (OS)

Open the THYM breakdown →