Across TCGA pan-cancer cohorts, TPRX1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of TPRX1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TPRX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TPRX1 is over-expressed in tumor.
KIRC are the cancer types where TPRX1 tumor–normal differential expression is most reproducible.