TPRX1

Across TCGA patient cohorts, TPRX1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPRX1-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and Fibronectin. Each is linked with TPRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRX1-to-partner and partner-to-TPRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by TPRX1-low versus TPRX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRX1→partner) and Y-score (partner→TPRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.292	-3.295	.016	.009	3	2
UCEC	EGFR_pY1068 →	-0.333	-3.169	.006	.019	3	1
UCEC	Fibronectin →	-0.313	-2.990	.049	.036	3	1
UCEC	Heregulin →	-0.180	-3.584	.002	.002	3	1
UCEC	Rab25 →	-0.425	-3.169	.007	.019	3	1
UCEC	Annexin-1 →	+0.834	+3.019	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Caspase-8 by TPRX1 expression — UCEC

Explore this box plot interactively →