TPRX1

Across TCGA cell cohorts, TPRX1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TPRX1-associated genes across cancer lineages are IFNK, MT4, and GJA10. Each is linked with TPRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRX1-to-partner and partner-to-TPRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNK grouped by TPRX1-low versus TPRX1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRX1→partner) and Y-score (partner→TPRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IFNK →	+0.026	+4.371	<.001	.005	3	1
BREAST	MT4 →	+0.155	+5.169	<.001	.005	3	1
BREAST	GJA10 →	+0.039	+5.169	<.001	.005	3	1
LARGE_INTESTINE	TMCO5A →	+0.027	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FAM162B →	+0.166	+4.095	<.001	.009	3	1
BLOOD_Leukemia	OLFM3 →	+0.598	+3.474	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

IFNK by TPRX1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →