TPRKB

Across TCGA patient cohorts, TPRKB mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPRKB-associated genes across cancer lineages are RNA5SP161, RNU6-956P, and MIR6864. Each is linked with TPRKB in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRKB-to-partner and partner-to-TPRKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP161 grouped by TPRKB-low versus TPRKB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRKB→partner) and Y-score (partner→TPRKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP161 →	+0.483	+5.097	<.001	.008	3	2
HNSC	RNU6-956P →	+0.366	+7.954	<.001	.008	3	1
UCEC	MIR6864 →	+1.158	+4.324	<.001	<.001	3	1
UCEC	RNVU1-19 →	+0.852	+3.692	<.001	.007	3	1
UCEC	MIR7845 →	+0.935	+4.160	<.001	<.001	3	1
SKCM	RN7SL272P →	+0.172	+5.594	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

RNA5SP161 by TPRKB expression — SKCM

Explore this box plot interactively →