TPRKB

Across TCGA pan-cancer cohorts, TPRKB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TPRKB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TPRKB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TPRKB is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where TPRKB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPRKB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.834	<.001	12	view →
KIRC	Female	All	+0.593	<.001	12	view →
BLCA	All	All	+0.644	<.001	11	view →
LIHC	Male	II,III,IV	+1.239	<.001	9	view →
KICH	Female	II,III,IV	−1.441	<.001	7	view →
LUAD	Male	II,III,IV	+0.651	<.001	7	view →
LUSC	Male	II,III,IV	+1.015	<.001	6	view →
BRCA	All	II,III,IV	+0.357	<.001	6	view →
CHOL	Male	All	+1.839	<.001	5	view →
STAD	All	II,III,IV	+0.441	.003	5	view →
THCA	All	All	−0.251	<.001	4	view →
ESCA	All	All	+0.708	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TPRKB–HNSC

Open the HNSC breakdown →