TPRA1

Across TCGA cell cohorts, TPRA1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TPRA1-associated genes across cancer lineages are C1QL2, SSMEM1, and WDR87. Each is linked with TPRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRA1-to-partner and partner-to-TPRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QL2 grouped by TPRA1-low versus TPRA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRA1→partner) and Y-score (partner→TPRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	2
LARGE_INTESTINE	SSMEM1 →	+0.029	+4.029	<.001	.002	3	1
LARGE_INTESTINE	WDR87 →	+0.017	+3.453	.003	.009	3	1
LARGE_INTESTINE	REG1B →	+2.248	+3.196	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.977	<.001	.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.093	+3.155	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

C1QL2 by TPRA1 expression — BLOOD_Leukemia

Explore this box plot interactively →