TPRA1

Across TCGA pan-cancer cohorts, TPRA1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TPRA1 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TPRA1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TPRA1 expression acts as an unfavorable survival marker, although some lineages such as UVM and DLBC show a favorable association.

BRCA, LIHC, and KIRC are the cancer types where TPRA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.785	0.912	.003	78	view →
LIHC	OS	Median	All	0.707	0.840	<.001	66	view →
KIRC	DFS	Quartile	All	0.819	0.926	<.001	57	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	55	view →
LGG	OS	Median	All	0.334	0.540	<.001	52	view →
UVM	OS	Median	All	0.841	0.556	<.001	52	view →
COAD	OS	Quartile	All	0.622	0.881	.003	38	view →
ACC	DFS	Tertile	All	0.196	0.700	<.001	30	view →
DLBC	DFS	Tertile	All	1.000	0.465	.012	24	view →
SCLC	DFS	Quartile	All	0.353	0.658	.015	14	view →
THYM	DFS	Tertile	All	0.917	0.705	.034	12	view →
SKCM	DFS	Tertile	IV	0.548	0.141	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TPRA1–BRCA (DFS)

Open the BRCA breakdown →