TPPP2

Across TCGA patient cohorts, TPPP2 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPPP2-associated genes across cancer lineages are Epithelial cells, Th2 cells, and Class-switched memory B-cells. Each is linked with TPPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPPP2-to-partner and partner-to-TPPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial cells grouped by TPPP2-low versus TPPP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPPP2→partner) and Y-score (partner→TPPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Epithelial cells →	-0.128	-3.161	<.001	.019	3	2
UCEC	Th2 cells →	+0.241	+3.177	.007	.010	2	1
UCEC	Class-switched memory B-cells →	-0.061	-2.321	.034	.036	1	1
UCEC	Plasma cells →	-0.026	-3.416	.016	.005	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Epithelial cells by TPPP2 expression — UCEC

Explore this box plot interactively →