TPPP2

Across TCGA pan-cancer cohorts, TPPP2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TPPP2 data layer compared with 3 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TPPP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TPPP2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRP show a favorable association.

STAD, LUAD, and KIRP are the cancer types where TPPP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.458	0.652	.002	97	view →
LUAD	OS	Tertile	All	0.548	0.307	<.001	97	view →
KIRP	DFS	Median	II,III,IV	1.000	0.324	.002	60	view →
LIHC	OS	Median	All	0.806	0.609	<.001	53	view →
CESC	OS	Quartile	All	0.943	0.814	.005	50	view →
LGG	DFS	Median	All	0.806	0.672	<.001	48	view →
UCEC	OS	Median	All	0.951	0.901	.002	42	view →
HNSC	DFS	Median	II,III,IV	0.475	0.257	.004	42	view →
UVM	DFS	Tertile	All	0.789	0.483	.007	31	view →
CHOL	DFS	Tertile	II,III,IV	0.085	0.708	.003	29	view →
BRCA	OS	Tertile	III,IV	0.725	0.312	.003	16	view →
KIRC	DFS	Median	IV	0.434	0.723	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TPPP2–STAD (OS)

Open the STAD breakdown →