TPPP2

Across TCGA pan-cancer cohorts, TPPP2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TPPP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TPPP2 RNA is repressed in tumor relative to normal tissue. In most cancer types TPPP2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where TPPP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPPP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.081	<.001	12	view →
KIRP	Male	III,IV	−1.204	<.001	11	view →
HNSC	Male	All	−0.355	<.001	10	view →
COAD	Male	All	−0.174	<.001	10	view →
LIHC	Male	III,IV	−1.571	<.001	8	view →
BRCA	All	III,IV	−0.451	<.001	8	view →
THCA	Female	II,III,IV	−0.124	<.001	7	view →
LUAD	Female	II,III,IV	−0.117	.001	7	view →
CHOL	Female	All	−2.030	<.001	5	view →
KICH	Male	All	−0.842	<.001	5	view →
LUSC	Male	All	−0.066	<.001	4	view →
READ	All	All	−0.107	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TPPP2–KIRC

Open the KIRC breakdown →