TPPP2

Across TCGA cell cohorts, TPPP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 305 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TPPP2-associated GO terms across cancer lineages are Negative regulation of T cell mediated cytotoxicity, Regulation of cytotoxic T cell degranulation, and Negative regulation of cytotoxic T cell degranulation. Each is linked with TPPP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TPPP2-to-partner and partner-to-TPPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of T cell mediated cytotoxicity grouped by TPPP2-low versus TPPP2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPPP2→partner) and Y-score (partner→TPPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of T cell mediated cytotoxicity →	+1.519	+0.209	<.001	.007	3	4
URINARY_TRACT	Regulation of cytotoxic T cell degranulation →	+1.145	+0.026	.005	.007	3	4
URINARY_TRACT	Negative regulation of cytotoxic T cell degranulation →	+1.145	+0.026	.005	.007	3	4
LUNG_SCLC	Nicotinamide nucleotide biosynthetic process →	+0.141	+0.025	.001	.002	3	4
LUNG_SCLC	Pyridine nucleotide biosynthetic process →	+0.141	+0.025	.001	.002	3	4
URINARY_TRACT	Response to epidermal growth factor →	+0.096	+0.051	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 305 associations by consensus.

Negative regulation of T cell mediated cytotoxicity by TPPP2 expression — STOMACH

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