TPPP

Across TCGA patient cohorts, TPPP mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPPP-associated genes across cancer lineages are Annexin-1, IGFBP2, and Ku80. Each is linked with TPPP in more than 1 cancer types. Because this analysis shows association rather than direction, both TPPP-to-partner and partner-to-TPPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TPPP-low versus TPPP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPPP→partner) and Y-score (partner→TPPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.578	+3.341	.018	.005	3	2
UCEC	IGFBP2 →	-0.769	-2.584	.011	.011	3	1
UCEC	Ku80 →	+0.262	+1.887	.017	.031	3	1
UCEC	Shc_pY317 →	-0.165	-3.169	.019	.019	3	1
UCEC	Transglutaminase →	+0.659	+2.584	.001	.011	3	1
UCEC	Caspase-7-cleavedD198 →	+0.822	+2.189	.002	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Annexin-1 by TPPP expression — UCEC

Explore this box plot interactively →