TPPP

Across TCGA pan-cancer cohorts, TPPP RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TPPP’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TPPP RNA is repressed in tumor relative to normal tissue. In most cancer types TPPP is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and LUAD are the cancer types where TPPP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPPP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.989	<.001	12	view →
THCA	Male	III,IV	−3.171	<.001	11	view →
LUAD	Male	III,IV	−2.848	<.001	11	view →
BRCA	All	III,IV	−1.776	<.001	8	view →
LUSC	Male	II,III,IV	−1.990	<.001	7	view →
UCEC	All	All	−2.340	<.001	6	view →
KICH	All	All	+0.958	.001	5	view →
READ	Female	All	−1.977	.049	1	view →
ESCA	All	All	−1.042	.048	1	view →
LIHC	All	All	+0.329	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TPPP–BLCA

Open the BLCA breakdown →