TPPP

Across TCGA pan-cancer cohorts, TPPP RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TPPP data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TPPP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TPPP expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

UVM, HNSC, and COAD are the cancer types where TPPP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.376	0.859	<.001	127	view →
HNSC	DFS	Tertile	IV	0.754	0.507	<.001	77	view →
COAD	DFS	Tertile	II,III,IV	0.333	0.840	<.001	65	view →
KIRC	OS	Tertile	All	0.751	0.533	<.001	52	view →
SKCM	OS	Tertile	All	0.249	0.424	<.001	27	view →
MESO	OS	Median	All	0.472	0.625	.022	23	view →
PAAD	OS	Tertile	All	0.517	0.252	.004	19	view →
LAML	DFS	Median	All	0.468	0.663	.003	18	view →
ESCA	DFS	Median	II,III,IV	0.432	0.880	.031	18	view →
UCEC	DFS	Quartile	II,III,IV	0.814	0.923	.021	16	view →
ACC	DFS	Quartile	All	0.370	0.717	.009	13	view →
LUAD	OS	Quartile	All	0.780	0.642	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TPPP–UVM (DFS)

Open the UVM breakdown →