TPPP

Across TCGA cell cohorts, TPPP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,465 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TPPP-associated GO terms across cancer lineages are Mitochondrial electron transport, NADH to ubiquinone, Aerobic respiration, and Proton motive force-driven ATP synthesis. Each is linked with TPPP in more than 11 cancer types. Because this analysis shows association rather than direction, both TPPP-to-partner and partner-to-TPPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial electron transport, NADH to ubiquinone grouped by TPPP-low versus TPPP-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPPP→partner) and Y-score (partner→TPPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Mitochondrial electron transport, NADH to ubiquinone →	+0.115	+1.806	<.001	<.001	3	12
LUNG_SCLC	Aerobic respiration →	+0.084	+1.166	<.001	<.001	3	11
LUNG_SCLC	Proton motive force-driven ATP synthesis →	+0.128	+1.819	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.116	+0.776	<.001	<.001	3	10
OVARY	Aerobic electron transport chain →	+0.102	+0.743	<.001	<.001	2	11
UPPER_AERODIGESTIVE_TRACT	Electron transport chain →	+0.106	+0.795	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,465 associations by consensus.

Mitochondrial electron transport, NADH to ubiquinone by TPPP expression — LUNG_SCLC

Explore this box plot interactively →