TPPP

Across TCGA cell cohorts, TPPP mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible TPPP-associated genes across cancer lineages are PIP, OR6N1, and LCE1F. Each is linked with TPPP in more than 1 cancer types. Because this analysis shows association rather than direction, both TPPP-to-partner and partner-to-TPPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIP grouped by TPPP-low versus TPPP-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPPP→partner) and Y-score (partner→TPPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PIP →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR6N1 →	+0.136	+4.807	<.001	.006	3	1
BLOOD_Myeloma	LCE1F →	+0.166	+4.807	<.001	.006	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PIP by TPPP expression — BLOOD_Myeloma

Explore this box plot interactively →