TPM3

Across TCGA patient cohorts, TPM3 mutation is significantly associated with the RNA expression of many other genes, with 1,188 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPM3-associated genes across cancer lineages are RNA5SP411, GEMIN4, and RCC1. Each is linked with TPM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPM3-to-partner and partner-to-TPM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by TPM3-low versus TPM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM3→partner) and Y-score (partner→TPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.689	+2.563	<.001	<.001	3	2
UCEC	GEMIN4 →	+0.542	+3.516	.003	.002	3	2
COAD	RCC1 →	+0.661	+3.223	<.001	.009	3	2
UCEC	SENP3-EIF4A1 →	+0.105	+3.726	.005	.001	3	2
COAD	PES1 →	+0.628	+3.249	<.001	.008	3	2
COAD	EIF3D →	+0.516	+3.210	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,188 associations by consensus.

RNA5SP411 by TPM3 expression — UCEC

Explore this box plot interactively →