TOPORSLP

Across TCGA patient cohorts, TOPORSLP RNA expression is significantly associated with the go_rna of many other GO terms, with 6,403 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TOPORSLP-associated GO terms across cancer lineages are Negative regulation of proteasomal protein catabolic process, Negative regulation of protein catabolic process, and Regulation of binding. Each is linked with TOPORSLP in more than 9 cancer types. Because this analysis shows association rather than direction, both TOPORSLP-to-partner and partner-to-TOPORSLP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of proteasomal protein catabolic process grouped by TOPORSLP-low versus TOPORSLP-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPORSLP→partner) and Y-score (partner→TOPORSLP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of proteasomal protein catabolic process →	+0.070	+0.077	<.001	<.001	3	10
STAD	Negative regulation of protein catabolic process →	+0.066	+0.081	<.001	<.001	3	10
STAD	Regulation of binding →	+0.063	+0.077	<.001	<.001	3	10
STAD	Positive regulation of DNA-templated transcription initiation →	+0.071	+0.074	<.001	<.001	3	9
STAD	Regulation of organelle assembly →	+0.064	+0.077	<.001	<.001	3	9
ESCA	Regulation of double-strand break repair →	+0.066	+0.081	<.001	.003	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,403 associations by consensus.

Negative regulation of proteasomal protein catabolic process by TOPORSLP expression — STAD

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