TOPORSLP

Across TCGA pan-cancer cohorts, TOPORSLP RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TOPORSLP data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TOPORSLP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOPORSLP expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUSC show a favorable association.

KIRC, READ, and MESO are the cancer types where TOPORSLP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.303	0.526	<.001	121	view →
READ	OS	Tertile	All	0.234	0.845	<.001	102	view →
MESO	OS	Tertile	All	0.052	0.528	.016	60	view →
THCA	DFS	Tertile	III,IV	0.687	0.939	.004	42	view →
BLCA	OS	Tertile	All	0.842	0.588	.005	39	view →
LUSC	DFS	Tertile	II,III,IV	0.859	0.580	.006	39	view →
SARC	DFS	Tertile	All	0.425	0.650	<.001	39	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
CHOL	OS	Tertile	All	0.089	0.673	.018	24	view →
HNSC	OS	Tertile	IV	0.542	0.373	.021	24	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
PAAD	OS	Tertile	II,III,IV	0.241	0.636	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TOPORSLP–KIRC (DFS)

Open the KIRC breakdown →