TOPORSLP

Across TCGA pan-cancer cohorts, TOPORSLP RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TOPORSLP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TOPORSLP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TOPORSLP is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, LUSC, and LIHC are the cancer types where TOPORSLP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOPORSLP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.004	.026	3	view →
LUSC	All	All	+0.012	.021	2	view →
LIHC	Female	All	+0.005	.045	1	view →
THCA	All	All	−0.004	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TOPORSLP–KIRC

Open the KIRC breakdown →