TOPAZ1

RNA expression — cross-omics
Cross-omicsRNA → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, TOPAZ1 RNA expression is significantly associated with the RNA expression of many other genes, with 342 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TOPAZ1-associated genes across cancer lineages are GH2, TNP2, and OR56A1. Each is linked with TOPAZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOPAZ1-to-partner and partner-to-TOPAZ1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOPAZ1 versus GH2 in LARGE_INTESTINE, with a Pearson correlation of 0.91.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPAZ1→partner) and Y-score (partner→TOPAZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LARGE_INTESTINEGH2 →+0.135+0.019<.001<.00133
STOMACHTNP2 →+0.070+0.015.001.00532
STOMACHOR56A1 →+0.058+0.026<.001<.00132
STOMACHOR52N5 →+0.048+0.026<.001<.00132
STOMACHTXNDC8 →+0.049+0.039<.001<.00132
LUNG_NSCLC_LUADOR11A1 →+0.059+0.004<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 342 associations by consensus.

TOPAZ1 vs GH2 — LARGE_INTESTINE

Per-sample scatter of TOPAZ1 vs GH2 in LARGE_INTESTINE (Pearson r = 0.91).

Explore this scatter interactively →

Exploration