TOPAZ1

Across TCGA pan-cancer cohorts, TOPAZ1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TOPAZ1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TOPAZ1 RNA is repressed in tumor relative to normal tissue. In most cancer types TOPAZ1 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, HNSC, and KICH are the cancer types where TOPAZ1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOPAZ1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−0.019	.017	7	view →
HNSC	All	III,IV	+0.010	.017	6	view →
KICH	Female	All	−0.016	.021	3	view →
THCA	All	IV	−0.012	.040	2	view →
LIHC	All	All	+0.006	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TOPAZ1–KIRP

Open the KIRP breakdown →