TOPAZ1

Across TCGA cell cohorts, TOPAZ1 RNA expression is significantly associated with the mutation status of many other genes, with 140 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TOPAZ1-associated genes across cancer lineages are CORIN, DHTKD1, and TDRD5. Each is linked with TOPAZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOPAZ1-to-partner and partner-to-TOPAZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CORIN grouped by TOPAZ1-low versus TOPAZ1-high in BREAST.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPAZ1→partner) and Y-score (partner→TOPAZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CORIN →	+5.169	+0.013	.005	<.001	3	2
STOMACH	DHTKD1 →	+4.285	+0.022	.007	<.001	3	2
LUNG_SCLC	TDRD5 →	+4.523	+0.031	.003	<.001	3	2
LUNG_NSCLC_LUAD	CILP2 →	+4.078	+0.007	.009	<.001	3	2
LUNG_NSCLC_LUAD	ITGAL →	+4.078	+0.007	.009	<.001	3	2
SKIN	POLQ →	+4.437	+0.008	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 140 associations by consensus.

CORIN by TOPAZ1 expression — BREAST

Explore this box plot interactively →