TOP2A

Across TCGA pan-cancer cohorts, TOP2A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TOP2A data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TOP2A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOP2A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where TOP2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.219	0.498	.002	73	view →
LUAD	OS	Median	II,III,IV	0.327	0.844	.005	11	view →
HNSC	DFS	Tertile	All	0.355	0.903	.014	10	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LSCC	DFS	Median	II,III,IV	0.820	0.564	.040	6	view →
OV	DFS	Median	All	0.874	1.000	.047	4	view →
CCRCC	DFS	Quartile	III,IV	0.271	0.793	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TOP2A–PDAC (DFS)

Open the PDAC breakdown →