TOP2A

Across TCGA pan-cancer cohorts, TOP2A mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TOP2A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TOP2A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TOP2A is over-expressed in tumor.

COAD, HNSC, and LUAD are the cancer types where TOP2A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOP2A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.077	<.001	12	view →
HNSC	Male	IV	+1.180	<.001	11	view →
LUAD	Male	III,IV	+1.329	<.001	9	view →
CCRCC	All	IV	+1.218	<.001	9	view →
LSCC	Male	II,III,IV	+1.794	<.001	8	view →
PDAC	Female	All	+1.071	<.001	7	view →
OV	All	All	+1.078	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TOP2A–COAD

Open the COAD breakdown →