TOMM40L

Across TCGA patient cohorts, TOMM40L mutation is significantly associated with the RNA expression of many other genes, with 497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOMM40L-associated genes across cancer lineages are NTF6A, RN7SL351P, and C2orf50. Each is linked with TOMM40L in more than 1 cancer types. Because this analysis shows association rather than direction, both TOMM40L-to-partner and partner-to-TOMM40L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTF6A grouped by TOMM40L-low versus TOMM40L-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOMM40L→partner) and Y-score (partner→TOMM40L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NTF6A →	+0.068	+4.969	<.001	.004	3	2
UCEC	RN7SL351P →	+0.280	+2.706	.005	<.001	3	2
UCEC	C2orf50 →	-0.960	-3.443	.004	.005	3	1
UCEC	CCDC3 →	-0.891	-3.700	.008	.001	3	1
UCEC	GPATCH11 →	+0.545	+3.502	.001	.002	3	1
UCEC	SAR1B →	+0.502	+3.483	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 497 associations by consensus.

NTF6A by TOMM40L expression — CESC

Explore this box plot interactively →