TOMM40L

Across TCGA pan-cancer cohorts, TOMM40L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TOMM40L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TOMM40L RNA is repressed in tumor relative to normal tissue. In most cancer types TOMM40L is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LIHC, and KICH are the cancer types where TOMM40L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOMM40L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.530	<.001	10	view →
LIHC	Female	II,III,IV	+2.481	<.001	9	view →
KICH	Male	All	−0.706	<.001	9	view →
BRCA	Female	All	+0.513	<.001	6	view →
KIRC	Male	II,III,IV	−0.500	<.001	6	view →
LUAD	All	All	+0.471	<.001	4	view →
CHOL	All	All	+1.647	<.001	3	view →
HNSC	Female	III,IV	+0.541	.016	3	view →
READ	All	All	−0.768	.006	2	view →
THCA	All	IV	−0.752	.004	2	view →
KIRP	Female	II,III,IV	+0.583	.036	2	view →
BLCA	All	All	+0.457	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TOMM40L–COAD

Open the COAD breakdown →