TOMM40L

Across TCGA pan-cancer cohorts, TOMM40L RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TOMM40L data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TOMM40L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TOMM40L expression acts as an unfavorable survival marker, although some lineages such as LUSC and KIRC show a favorable association.

LIHC, ACC, and UVM are the cancer types where TOMM40L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.586	0.811	<.001	85	view →
ACC	DFS	Median	All	0.421	0.744	<.001	80	view →
UVM	DFS	Quartile	III,IV	0.385	0.945	.001	60	view →
KICH	DFS	Median	II,III,IV	0.550	1.000	.002	59	view →
UCEC	DFS	Median	All	0.556	0.728	<.001	58	view →
LAML	DFS	Tertile	All	0.329	0.693	<.001	48	view →
READ	DFS	Median	III,IV	0.588	0.867	.008	36	view →
BLCA	OS	Quartile	IV	0.228	0.660	<.001	28	view →
ESCA	DFS	Median	III,IV	0.328	0.537	.003	26	view →
COAD	DFS	Median	III,IV	0.384	0.642	.002	19	view →
CESC	DFS	Tertile	III,IV	0.298	0.736	.012	12	view →
BRCA	OS	Quartile	II,III,IV	0.883	0.942	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TOMM40L–LIHC (OS)

Open the LIHC breakdown →