TOMM40L

Across TCGA patient cohorts, TOMM40L mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOMM40L-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with TOMM40L in more than 1 cancer types. Because this analysis shows association rather than direction, both TOMM40L-to-partner and partner-to-TOMM40L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TOMM40L-low versus TOMM40L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOMM40L→partner) and Y-score (partner→TOMM40L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.729	-2.321	.001	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.838	+2.827	.004	.035	3	2
UCEC	EGFR_pY1068 →	-0.371	-3.459	.003	.005	3	1
UCEC	GATA6 →	-0.210	-2.985	.006	.034	3	1
UCEC	MEK1 →	+0.470	+3.321	.010	.010	3	1
UCEC	Notch1 →	+0.141	+2.321	.046	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATM by TOMM40L expression — UCEC

Explore this box plot interactively →