TOLLIP

Across TCGA patient cohorts, TOLLIP protein abundance is significantly associated with the RNA expression of many other genes, with 18,242 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TOLLIP-associated genes across cancer lineages are CENPI, NCAPG, and RAD51AP1. Each is linked with TOLLIP in more than 6 cancer types. Because this analysis shows association rather than direction, both TOLLIP-to-partner and partner-to-TOLLIP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOLLIP versus CENPI in BRCA, with a Pearson correlation of -0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOLLIP→partner) and Y-score (partner→TOLLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CENPI →	-0.749	-0.345	<.001	<.001	3	7
BRCA	NCAPG →	-1.328	-0.485	<.001	<.001	3	7
HNSC	RAD51AP1 →	-0.797	-0.265	<.001	<.001	3	7
BRCA	FBXO5 →	-0.751	-0.340	<.001	<.001	3	7
HNSC	LMNB1 →	-0.886	-0.353	<.001	<.001	3	7
BRCA	NEK2 →	-1.025	-0.313	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,242 associations by consensus.

TOLLIP vs CENPI — BRCA

Explore this scatter interactively →