TOLLIP

Across TCGA pan-cancer cohorts, TOLLIP RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TOLLIP’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TOLLIP RNA is repressed in tumor relative to normal tissue. In most cancer types TOLLIP is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LUAD, KIRP, and LIHC are the cancer types where TOLLIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOLLIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.493	<.001	11	view →
KIRP	Male	III,IV	−0.532	<.001	8	view →
LIHC	Male	All	+0.433	<.001	8	view →
THCA	All	IV	−0.629	.001	7	view →
COAD	All	All	+0.208	.018	4	view →
UCEC	All	All	−0.413	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TOLLIP–LUAD

Open the LUAD breakdown →