TOLLIP

Across TCGA patient cohorts, TOLLIP mutation is significantly associated with the RNA expression of many other genes, with 1,559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOLLIP-associated genes across cancer lineages are ATF4P1, IGLV3-7, and RNU6-1250P. Each is linked with TOLLIP in more than 1 cancer types. Because this analysis shows association rather than direction, both TOLLIP-to-partner and partner-to-TOLLIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4P1 grouped by TOLLIP-low versus TOLLIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOLLIP→partner) and Y-score (partner→TOLLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF4P1 →	+0.051	+2.525	<.001	<.001	3	2
UCEC	IGLV3-7 →	+0.124	+1.951	.004	.008	3	2
SKCM	RNU6-1250P →	+0.432	+7.209	<.001	<.001	3	2
HNSC	C1QBPP1 →	+0.077	+6.111	<.001	.002	3	2
UCEC	CRYBB2P1 →	+0.410	+1.869	.005	.005	3	1
UCEC	MFNG →	+0.649	+2.512	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,559 associations by consensus.

ATF4P1 by TOLLIP expression — UCEC

Explore this box plot interactively →