TOE1

Across TCGA patient cohorts, TOE1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOE1-associated genes across cancer lineages are p27_pT198, Annexin-1, and eEF2. Each is linked with TOE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOE1-to-partner and partner-to-TOE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by TOE1-low versus TOE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOE1→partner) and Y-score (partner→TOE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.106	+2.087	.009	.005	3	2
UCEC	Annexin-1 →	+0.475	+3.341	.018	.005	3	2
UCEC	eEF2 →	+0.338	+2.000	.013	.030	3	1
UCEC	EGFR_pY1068 →	-0.214	-1.678	.026	.023	3	1
UCEC	eIF4E →	+0.196	+2.087	.015	.005	3	1
UCEC	ERK2 →	+0.235	+2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p27_pT198 by TOE1 expression — UCEC

Explore this box plot interactively →