TOE1

Across TCGA cell cohorts, TOE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,880 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TOE1-associated GO terms across cancer lineages are Mitotic DNA replication checkpoint signaling, DNA replication checkpoint signaling, and Positive regulation of mitotic cell cycle phase transition. Each is linked with TOE1 in more than 16 cancer types. Because this analysis shows association rather than direction, both TOE1-to-partner and partner-to-TOE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication checkpoint signaling grouped by TOE1-low versus TOE1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOE1→partner) and Y-score (partner→TOE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitotic DNA replication checkpoint signaling →	+0.161	+0.865	.005	<.001	3	17
BONE	DNA replication checkpoint signaling →	+0.190	+0.915	.001	<.001	3	17
SKIN	Positive regulation of mitotic cell cycle phase transition →	+0.101	+0.817	<.001	<.001	3	17
BONE	DNA replication initiation →	+0.153	+0.662	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated DNA replication →	+0.156	+0.940	<.001	<.001	3	16
SKIN	Positive regulation of cell cycle phase transition →	+0.096	+0.798	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,880 associations by consensus.

Mitotic DNA replication checkpoint signaling by TOE1 expression — BONE

Explore this box plot interactively →