TNRC6B

Across TCGA patient cohorts, TNRC6B mutation is significantly associated with the RNA expression of many other genes, with 6,815 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNRC6B-associated genes across cancer lineages are ZNF662, PTMAP4, and MTFP1. Each is linked with TNRC6B in more than 4 cancer types. Because this analysis shows association rather than direction, both TNRC6B-to-partner and partner-to-TNRC6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF662 grouped by TNRC6B-low versus TNRC6B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC6B→partner) and Y-score (partner→TNRC6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF662 →	-0.469	-2.083	.007	.001	3	5
COAD	PTMAP4 →	+0.846	+1.926	.004	.008	3	4
COAD	MTFP1 →	+0.486	+2.341	<.001	.003	3	4
COAD	LINC02446 →	+0.783	+2.097	<.001	.003	3	4
UCEC	CDC45 →	+0.649	+1.799	<.001	<.001	3	4
UCEC	CCDC89 →	-0.527	-1.241	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,815 associations by consensus.

ZNF662 by TNRC6B expression — COAD

Explore this box plot interactively →