TNRC6B

Across TCGA pan-cancer cohorts, TNRC6B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TNRC6B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TNRC6B RNA is repressed in tumor relative to normal tissue. In most cancer types TNRC6B is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where TNRC6B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNRC6B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.625	<.001	9	view →
LIHC	Female	III,IV	+0.855	<.001	8	view →
HNSC	Male	II,III,IV	+0.582	<.001	8	view →
BRCA	All	III,IV	−0.415	<.001	6	view →
CHOL	Male	All	+1.530	<.001	5	view →
LUSC	All	All	+0.378	<.001	5	view →
COAD	Female	All	−0.363	.018	4	view →
UCEC	All	All	−0.605	.002	2	view →
PRAD	All	All	+0.345	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TNRC6B–THCA

Open the THCA breakdown →