TNR

Across TCGA patient cohorts, TNR protein abundance is significantly associated with the RNA expression of many other genes, with 15,054 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TNR-associated genes across cancer lineages are ZCCHC24, VAT1L, and FAM107B. Each is linked with TNR in more than 2 cancer types. Because this analysis shows association rather than direction, both TNR-to-partner and partner-to-TNR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNR versus ZCCHC24 in BRCA, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNR→partner) and Y-score (partner→TNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZCCHC24 →	+0.965	+1.147	.003	.001	3	3
GBM	VAT1L →	+1.974	+0.957	<.001	<.001	3	3
GBM	FAM107B →	+0.880	+0.642	<.001	.001	3	3
LUAD	TMEM245 →	-0.451	-0.384	.002	.009	3	2
BRCA	SOBP →	+0.456	+0.962	<.001	.004	2	3
LSCC	SMC4 →	-0.594	-0.706	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,054 associations by consensus.

TNR vs ZCCHC24 — BRCA

Explore this scatter interactively →