TNR

Across TCGA pan-cancer cohorts, TNR RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TNR’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TNR RNA is repressed in tumor relative to normal tissue. In most cancer types TNR is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BRCA are the cancer types where TNR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−1.372	<.001	8	view →
LUAD	All	III,IV	−1.330	<.001	8	view →
BRCA	Female	All	+0.238	<.001	6	view →
COAD	All	II,III,IV	−0.073	<.001	6	view →
LIHC	All	All	−0.198	.003	5	view →
KICH	All	All	−0.075	<.001	4	view →
KIRC	All	All	+0.139	.008	3	view →
BLCA	Female	III,IV	−0.120	.014	3	view →
THCA	All	All	−0.081	.003	3	view →
KIRP	All	All	−0.050	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TNR–LUSC

Open the LUSC breakdown →