TNK1

Across TCGA patient cohorts, TNK1 mutation is significantly associated with the RNA expression of many other genes, with 509 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNK1-associated genes across cancer lineages are LINC02647, SS18L2P2, and RNA5SP407. Each is linked with TNK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TNK1-to-partner and partner-to-TNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02647 grouped by TNK1-low versus TNK1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNK1→partner) and Y-score (partner→TNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02647 →	+0.294	+7.640	<.001	.009	3	4
COAD	SS18L2P2 →	+0.112	+4.109	<.001	.007	3	3
BLCA	RNA5SP407 →	+0.577	+7.640	<.001	.009	3	2
UCEC	RN7SL248P →	+0.066	+3.219	<.001	.004	3	2
UCEC	HEXIM1 →	+0.589	+3.180	<.001	<.001	3	2
UCEC	PRAMEF7 →	+0.121	+2.096	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 509 associations by consensus.

LINC02647 by TNK1 expression — BLCA

Explore this box plot interactively →