TNK1

Across TCGA pan-cancer cohorts, TNK1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TNK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TNK1 RNA is repressed in tumor relative to normal tissue. In most cancer types TNK1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and HNSC are the cancer types where TNK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.195	<.001	11	view →
THCA	All	II,III,IV	−0.408	<.001	11	view →
HNSC	Male	III,IV	+1.051	<.001	10	view →
BLCA	All	III,IV	+1.032	.001	8	view →
COAD	Female	II,III,IV	−0.694	<.001	8	view →
LUSC	Male	All	+0.710	<.001	6	view →
CHOL	All	All	+1.592	<.001	5	view →
READ	Male	All	−1.066	.028	5	view →
LUAD	All	All	+0.280	.002	5	view →
STAD	Male	All	+0.846	.002	4	view →
BRCA	All	II,III,IV	+0.437	.003	4	view →
UCEC	All	All	+0.744	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TNK1–KICH

Open the KICH breakdown →