TNIP1

Across TCGA cell cohorts, TNIP1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNIP1-associated genes across cancer lineages are CLDN17, LIPK, and PRAMEF20. Each is linked with TNIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNIP1-to-partner and partner-to-TNIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN17 grouped by TNIP1-low versus TNIP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNIP1→partner) and Y-score (partner→TNIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1
LARGE_INTESTINE	LIPK →	+0.237	+3.554	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	LRRC3C →	+0.307	+3.658	<.001	.005	3	1
LARGE_INTESTINE	F11 →	+0.041	+3.882	.001	.001	3	1
LUNG_NSCLC_LUAD	OPN1LW →	+0.038	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CLDN17 by TNIP1 expression — LARGE_INTESTINE

Explore this box plot interactively →